UNC2025 hydrochloride

An orally bioavailable inhibitor of Mer and Flt3

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库存: 现货

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促销价

数量
2mg

￥512.00

410.00

- +
5mg

￥850.00

680.00

- +
10mg

￥1437.00

1150.00

- +
25mg

￥2375.00

1900.00

- +
50mg

￥4025.00

3220.00

- +
100mg

￥6712.00

5370.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

UNC2025 is a potent, orally bioavailable inhibitor of the tyrosine kinases Mer and Flt3 (IC₅₀s = 0.74 and 0.80 nM, respectively).¹ It less potently inhibits Axl and Tyro3 (IC₅₀s = 14 and 17 nM, respectively) and a panel of related kinases.¹ UNC2025 blocks colony formation of Mer- and Flt3-dependent tumor cell lines and inhibits Mer phosphorylation in bone marrow leukemia cells in vivo.¹ Pharmacokinetic studies suggest that orally administered UNC2025 at 3 mg/kg will suffice to provide 90% inhibition of Mer and Flt3 at 30 min.¹

1.Zhang, W., DeRychere, D., Hunter, D., et al.UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitorJ. Med. Chem.57(16)7031-7041(2014)