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  • UNC2025 hydrochloride
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UNC2025 hydrochloride

An orally bioavailable inhibitor of Mer and Flt3

原价
¥512-6712
价格
410-5370
UNC2025 hydrochloride的二维码

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  • 库存: 现货
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  • 货号: ajcx14164
  • CAS: 2070015-17-5
  • 别名:
  • 分子式: C28H41ClN6O
  • 分子量: 513.12
  • 纯度: >98%
  • 溶解度: DMSO: 6.66 mg/mL (12.98 mM)
  • 储存: Store at -20°C
  • 库存: 现货

Background

UNC2025 is a potent, orally bioavailable inhibitor of the tyrosine kinases Mer and Flt3 (IC50s = 0.74 and 0.80 nM, respectively).1 It less potently inhibits Axl and Tyro3 (IC50s = 14 and 17 nM, respectively) and a panel of related kinases.1 UNC2025 blocks colony formation of Mer- and Flt3-dependent tumor cell lines and inhibits Mer phosphorylation in bone marrow leukemia cells in vivo.1 Pharmacokinetic studies suggest that orally administered UNC2025 at 3 mg/kg will suffice to provide 90% inhibition of Mer and Flt3 at 30 min.1


1.Zhang, W., DeRychere, D., Hunter, D., et al.UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitorJ. Med. Chem.57(16)7031-7041(2014)

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