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- ALK (Anaplastic lymphoma kinase)
- Fuziline
Fuziline
A diterpene alkaloid with cardioprotective activity
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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1mg￥437.00350.00- +
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5mg￥1300.001040.00- +
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10mg￥2062.001650.00- +
- 货号: ajcx14198
- CAS: 80665-72-1
- 别名: 附子灵; 15α-Hydroxyneoline
- 分子式: C24H39NO7
- 分子量: 453.57
- 纯度: ＞98%
- 溶解度: Chloroform: soluble,DMSO: soluble
- 储存: Store at -20°C
- 库存: 现货
Background
Fuziline is a diterpene alkaloid that has been found in A. lateralis and has cardioprotective activity.1 It reduces sodium pentobarbital-induced cell death in primary neonatal rat cardiomyocytes when used at concentrations ranging from 0.1 to 10 ?M. Fuziline (0.5 ?M) reduces the production of reactive oxygen species (ROS) and apoptosis induced by isoproterenol in H9c2 rat cardiomyocytes.2 In vivo, fuziline (3 and 10 mg/kg) reduces isoproterenol-induced myocardial necrosis and fibrosis in rats.
1.Xiong, L., Peng, C., Xie, X.-F., et al.Alkaloids isolated from the lateral root of Aconitum carmichaeliiMolecules17(8)9939-9946(2012) 2.Fan, C.-L., Yao, Z.-H., Ye, M.-N., et al.Fuziline alleviates isoproterenol-induced myocardial injury by inhibiting ROS-triggered endoplasmic reticulum stress via PERK/eIF2α/ATF4/Chop pathwayJ. Cell Mol. Med.24(2)1332-1344(2020)
