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- Direct Black 38
Direct Black 38
An iron uptake inhibitor，dye content ≥45%(based on Nitrogen)
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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100mg￥212.00170.00- +
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200mg￥0.000.00- +
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500mg￥0.000.00- +
- 货号: ajcx14262
- CAS: 1937-37-7
- 别名: 直接黑38,Chlorazol Black E; Ferristatin II disodium; C.I. 30235
- 分子式: C34H25N9Na2O7S2
- 分子量: 781.73
- 纯度: ＞98%
- 溶解度: Water: 5 mg/mL (6.40 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
Ferristatin II is an inhibitor of iron uptake.1 It inhibits iron uptake (IC50 = ~12 ?M), as well as induces degradation of transferrin receptor protein 1 (TfR1), an effect that can be reversed by the lipid membrane disruptor nystatin, in HeLa cells. In vivo ferristatin II (0.2, 10, and 40 mg/kg) reduces serum iron levels and transferrin saturation in rats. It also suppresses traumatic brain injury-induced lipid peroxidation, neuronal apoptosis, and the number of cortical iron deposits in rats.2
1.Byrne, S.L., Buckett, P.D., Kim, J., et al.Ferristatin II promotes degradation of transferrin receptor-1 in vitro and in vivoPLoS One8(7)e70199(2013) 2.Cheng, Y., Qu, W., Li, J., et al.Ferristatin II, an iron uptake inhibitor, exerts neuroprotection against traumatic brain injury via suppressing ferroptosisACS Chem. Neurosci.13(5)664-675(2022)
