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FAK ligand-Linker Conjugate 1 包含靶蛋白 FAK 配体和 PROTAC linker,可募集 E3 连接酶 (如 VHL,CRBN,MDM2 和 IAP 等类型)。FAK ligand-Linker Conjugate 1 可广泛用于 PROTAC 介导的蛋白降解。
FAK ligand-Linker Conjugate 1 incorporates a ligand for FAK, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). FAK ligand-Linker Conjugate 1 can be extensively used for PROTAC-mediated protein degradation[1].
[1]. Cromm PM, et al. Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation. J Am Chem Soc. 2018 Dec 12;140(49):17019-17026.
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