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  • BMS-1166 hydrochloride
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BMS-1166 hydrochloride

A PD-1/PD-L1 interaction inhibitor

原价
¥2500-17637
价格
2000-14110
BMS-1166 hydrochloride的二维码

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  • 货号: ajcx14370
  • CAS: 2113650-05-6
  • 别名:
  • 分子式: C36H34Cl2N2O7
  • 分子量: 677.57
  • 纯度: >98%
  • 溶解度: Soluble in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

BMS 1166 is an inhibitor of the protein-protein interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 that has an IC50 value of 1.4 nM in a homologous time-resolved fluorescence (HTRF) assay.1 It increases the activation of Jurkat cells expressing PD-1 in co-culture with CHO cells expressing PD-L1 (EC50 = 276 nM in a reporter assay).2


1.Guzik, K., Zak, K.M., Grudnik, P., et al.Small-molecule inhibitors of the programmed cell death-1/programmed death-ligand 1 (PD-1/PD-L1) interaction via transiently induced protein states and dimerization of PD-L1J. Med. Chem.60(13)5857-5867(2017) 2.Skalniak, L., Zak, K.M., Guzik, K., et al.Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cellsOncotarget8(42)72167-72181(2017)

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