An alkaloid and a toxin
Deltaline is an alkaloid and a toxin that has been found in D. barbeyi.1,2 It reduces sciatic nerve stimulation-induced compound muscle action potentials (CMAPs) in isolated lizard extensor digitorum longus muscle (IC50 = 156 ?M).1 Deltaline (85 mg/kg) increases the number of falls from a beam and decreases the time spent mobile in an open field test, markers of neuromuscular impairment, in mice.2 It also induces lethality in mice (LD50 = 113 mg/kg).
1.Dobelis, P., Madl, J.E., Pfister, J.A., et al.Effects of Delphinium alkaloids on neuromuscular transmissionJ. Pharmacol. Exp. Ther.291(2)538-546(1999) 2.Welch, K.D., Pfister, J.A., Lima, F.G., et al.Effect of α? nicotinic acetylcholine receptor agonists and antagonists on motor function in miceToxicol. Appl. Pharmacol.66(3)366-374(2013)
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