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- Acetyl-CoA carboxylase (ACC)
- ZM223 hydrochloride
ZM223 hydrochloride
ZM223 hydrochloride 是一种有效的非共价 NEDD8 活化酶 (NAE) 抑制剂，具有口服活性。
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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5mg￥2612.002090.00- +
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10mg￥3662.002930.00- +
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50mg￥10575.008460.00- +
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100mg￥16025.0012820.00- +
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200mg￥0.000.00- +
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500mg￥0.000.00- +
- 货号: ajcx14402
- CAS: N/A
- 别名:
- 分子式: C23H18ClF3N4O2S2
- 分子量: 538.99
- 纯度: ＞98%
- 溶解度: DMSO: 150 mg/mL (278.30 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
ZM223 hydrochloride is an orally active, potent non-covalent NEDD8 activating enzyme (NAE) inhibitor with excellent anticancer activity[1].
ZM223 hydrochloride (0.1-1 μM; 4 hours) inhibits both HCT-116 and U-2OS cancer cells with IC50s of 100 and 122 nM, respectively[1].ZM223 hydrochloride (0.1-1 μM; 4 hours) causes a dose-response decrease in the level of NEDD8 and accumulation of the UBC12 protein, indicating the decrease of the subsequent NEDD8-UBC12 complex[1]. Cell Viability Assay[1] Cell Line: HCT116 colon cancer cells and U-2OS osteosarcoma cells
[1]. Ma H, et al. Discovery of benzothiazole derivatives as novel non-sulfamide NEDD8 activating enzyme inhibitors by target-based virtual screening. Eur J Med Chem. 2017 Jun 16;133:174-183.
