WJ460

WJ460 是一种有效的肌成纤维蛋白 (MYOF) 抑制剂，可与 MYOF 直接相互作用，并在乳腺癌细胞的纳摩尔范围内发挥抗转移活性。

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库存: 现货

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包装

价格

促销价

数量
1mg

￥425.00

340.00

- +
5mg

￥1350.00

1080.00

- +
10mg

￥2287.00

1830.00

- +
25mg

￥3775.00

3020.00

- +
50mg

￥6462.00

5170.00

- +
100mg

￥10912.00

8730.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

WJ460 is a potent myoferlin (MYOF) inhibitor, which interacts directly with MYOF and exerts anti-metastatic activity in the nanomolar range in breast cancer cells[1].

WJ460 blocks breast cancer cell invasion with IC50 values of 43.37 ± 3.42 nM in MDA-MB-231 and 36.40 ± 4.51 nM in BT549 cells. WJ460 treatment remarkably inhibits MDA-MB-231 and BT549 cell invasion through Collagen I in a dose-dependent manner[1].

WJ460 inhibits breast tumor growth, angiogenesis, and spontaneous metastasis in a spontaneous metastasis model[1].

[1]. Zhang T, et al. A small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer. Nat Commun. 2018 Sep 13;9(1):3726.