Farrerol, an important bioactive constituent of rhododendron, exhibits broad activities such as anti-oxidative and anti-inflammatory effects.
Farrerol, an important bioactive constituent of rhododendron, exhibits broad activities such as anti-oxidative and anti-inflammatory effects.
Farrerol observably reduces the production of inflammatory mediators including IL-1β, IL-6, TNF-α, COX-2, and iNOS in LPS-induced RAW264.7 cells via suppressing AKT, ERK1/2, JNK1/2, and NF-κB p65 phosphorylation.[1]
In 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis model, Farrerol has a protective effect on TNBS-induced colitis. Farrerol administration significantly improves the weight change, clinical scores, colon length, and intestinal epithelium barrier damage and markedly decreases the production of the inflammatory cytokines in TNBS-induced mice. [1]
[1] Ran X, et al. Int J Mol Sci. 2018 Jul 13;19(7):2037.
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