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A tetrahydroberberine alkaloid
D-Tetrahydropalmatine is a tetrahydroberberine alkaloid that has been found in Corydalis.1 In vivo, D-Tetrahydropalmatine (32 mg/kg) reverses apomorphine-induced inhibition of dopaminergic firing in the substantia nigra pars compacta (SNC) in paralyzed rats.2
1.Liao, J., Liang, W.-Z., and Tu, G.-S.Isolation and identification of eleven tertiary alkaloids in Corydalis decumbensJ. Chin. Pharma. Sci.4(2)57-61(1995) 2.Sun, B.C., Huang, K.X., and Jin, G.Z.Comparison of effects of tetrahydropalmatine enantiomers on firing activity of dopamine neurons in substantia nigra pars compactaZhongguo Yao Li Xue Bao13(4)292-297(1992)
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