现货大促销,价格低至8折起,量大更优惠,详细咨询客服
全部分类
全部分类
  • WYE-687 dihydrochloride
WYE-687 dihydrochloride的可视化放大

WYE-687 dihydrochloride

An mTOR inhibitor

原价
¥2612-7775
价格
2090-6220
WYE-687 dihydrochloride的二维码

所有产品仅用于科学研究,我们不为任何个人用途提供产品和服务

询价有惊喜,量大更优惠 点击这里给我发消息

  • 库存: 现货
可选包装 >>>
首页
  • 货号: ajcx14834
  • CAS: 1702364-87-1
  • 别名: WYE-687二盐酸盐
  • 分子式: C28H34Cl2N8O3
  • 分子量: 601.53
  • 纯度: >98%
  • 溶解度: Soluble in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

WYE-687 is an inhibitor of mammalian target of rapamycin (mTOR; IC50 = 0.007 ?M).1 It is selective for mTOR over PI3Kα and PI3Kγ (IC50s = 0.81 and 3.11 ?M, respectively), as well as a panel of 24 additional kinases (IC50s = >50 ?M for all). WYE-687 (0.2, 1, and 5 ?M) decreases phosphorylation of the mTORC1 and mTORC2 substrates Akt and S6 kinase (S6K1) in a cell-free assay. It decreases proliferation of nine cancer cell lines, including breast, prostate, glioma, kidney, and colorectal cancer cells, with IC50 values ranging from 0.18 to 1.25 ?M. WYE-687 inhibits survival of HL-60 and U937 leukemia cells in a concentration-dependent manner and reduces tumor growth in a U937 mouse xenograft model when administered at doses of 5 and 25 mg/kg.2


1.Yu, K., Toral-Barza, L., Shi, C., et al.Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycinCancer Res.69(15)6232-6240(2009) 2.Cheng, F., Wang, L., Shen, Y., et al.Preclinical evaluation of WYE-687, a mTOR kinase inhibitor, as a potential anti-acute myeloid leukemia agentBiochem. Biophys. Res. Commun.470(2)324-330(2016)

动态评分

0.0

没有评分数据
没有评价数据
一键回到顶部
展开 收缩
安捷凯在线客服