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- Aldose Reductase
- Groenlandicine
Groenlandicine
Groenlandicine 是从黄连中分离得到的一种原小檗碱生物碱。Groenlandicine 对人类重组醛糖还原酶 (HRAR) 具有中度的抑制作用，IC50 值为 154.2 μM。Groenlandicine 能诱导拓扑异构酶 I (topoisomerase I) 介导的 DNA 裂解。
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包装价格促销价数量
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1mg￥2062.001650.00- +
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5mg￥6150.004920.00- +
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- 货号: ajcx14892
- CAS: 38691-95-1
- 别名: 格兰地新
- 分子式: C19H16NO4+
- 分子量: 322.33
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: 4°C, protect from light
- 库存: 现货
Background
Groenlandicine is a protoberberine alkaloid isolated from Coptidis Rhizoma. Groenlandicine exhibits moderate inhibitory effect with IC50 value of 154.2 μM for human recombinant aldose reductase (HRAR)[1]. Groenlandicine selectively induces topoisomerase I-mediated DNA cleavage[2].
[1]. Jung HA, et al. Inhibitory activities of the alkaloids from Coptidis Rhizoma against aldose reductase. Arch Pharm Res. 2008 Nov;31(11):1405-12. [2]. Kobayashi Y, et al. Inhibitors of DNA topoisomerase I and II isolated from the Coptis rhizomes. Planta Med. 1995 Oct;61(5):414-8.
