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- TNF Receptor
- T6167923
T6167923
T6167923是一种有效的、选择性的 MyD88 依赖性信号通路抑制剂。T6167923 直接与 MyD88 的 Toll/IL1 受体 (TIR) 结构域结合，破坏 MyD88 的同二聚体形成。T6167923 抑制 NF-κB 驱动的葡萄球菌肠毒素AP (SEAP) 活性，并且改善抗炎活性，对 IFN-γ，IL-1β，IL-6 和 TNF-α 的 IC50 分别为 2.7 μM，2.9 μM，2.66 μM 和 2.66 μM。
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包装价格促销价数量
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1mg￥2062.001650.00- +
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5mg￥6037.004830.00- +
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10mg￥10250.008200.00- +
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25mg￥16025.0012820.00- +
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50mg￥26712.0021370.00- +
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100mg￥42750.0034200.00- +
- 货号: ajcx14902
- CAS: 2437475-16-4
- 别名:
- 分子式: C17H20BrN3O3S2
- 分子量: 458.39
- 纯度: ＞98%
- 溶解度: DMSO: 250 mg/mL (545.39 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
T6167923 is a potent and selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity, and improves anti-inflammatory activity with an 50 of 2.7 μM, 2.9 μM, 2.66 μM and 2.66 μM for IFN-γ, IL-1β, IL-6 and TNF-α, respectively[1].
[1]. Saqib U, et al. Identifying the inhibition of TIR proteins involved in TLR signalling as an anti-inflammatory strategy. SAR QSAR Environ Res. 2018 Apr;29(4):295-318. [2]. Olson MA, et al. Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen. Sci Rep. 2015 Sep 18;5:14246.
