现货大促销,价格低至8折起,量大更优惠,详细咨询客服
全部分类
全部分类
  • AMG-548 dihydrochloride
AMG-548 dihydrochloride的可视化放大

AMG-548 dihydrochloride

An inhibitor of p38α MAPK

价格
0-12390
AMG-548 dihydrochloride的二维码

所有产品仅用于科学研究,我们不为任何个人用途提供产品和服务

询价有惊喜,量大更优惠 点击这里给我发消息

  • 库存: 现货
可选包装 >>>
首页
  • 货号: ajcx14906
  • CAS: N/A
  • 别名:
  • 分子式: C29H29Cl2N5O
  • 分子量: 534.48
  • 纯度: >98%
  • 溶解度: Soluble in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

AMG 548 is an inhibitor of p38α MAPK (Ki = 0.5 nM).1 It is selective for p38α over p38γ, p38δ, JNK1, JNK2, and JNK3 (Kis = 2,600, 4,100, 11,480, 39, and 61 nM, respectively) and is greater than 1,000-fold selective over a panel of 36 additional kinases but also inhibits p38β (Ki = 3.6 nM). AMG 548 inhibits LPS-induced production of TNF-α and IL-1β in isolated human whole blood (IC50s = 3 and 7 nM, respectively).


1.Lee, M.R., and Dominguez, C.MAP kinase p38 inhibitors: Clinical results and an intimate look at their interactions with p38α proteinCurr. Med. Chem.12(25)2979-2994(2005)

动态评分

0.0

没有评分数据
没有评价数据
一键回到顶部
展开 收缩
安捷凯在线客服