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- PKD (Protein kinase D)
- AMG-548 dihydrochloride
AMG-548 dihydrochloride
An inhibitor of p38α MAPK
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包装价格促销价数量
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1mg￥987.00790.00- +
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5mg￥2937.002350.00- +
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10mg￥4850.003880.00- +
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25mg￥9712.007770.00- +
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50mg￥15487.0012390.00- +
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100mg￥0.000.00- +
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- 货号: ajcx14906
- CAS: N/A
- 别名:
- 分子式: C29H29Cl2N5O
- 分子量: 534.48
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
AMG 548 is an inhibitor of p38α MAPK (Ki = 0.5 nM).1 It is selective for p38α over p38γ, p38δ, JNK1, JNK2, and JNK3 (Kis = 2,600, 4,100, 11,480, 39, and 61 nM, respectively) and is greater than 1,000-fold selective over a panel of 36 additional kinases but also inhibits p38β (Ki = 3.6 nM). AMG 548 inhibits LPS-induced production of TNF-α and IL-1β in isolated human whole blood (IC50s = 3 and 7 nM, respectively).
1.Lee, M.R., and Dominguez, C.MAP kinase p38 inhibitors: Clinical results and an intimate look at their interactions with p38α proteinCurr. Med. Chem.12(25)2979-2994(2005)
