CP-547632 hydrochloride

A potent inhibitor of VEGFR2 and bFGF

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库存: 现货

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数量
5mg

￥1087.00

870.00

- +
10mg

￥1962.00

1570.00

- +
50mg

￥6150.00

4920.00

- +
100mg

￥10575.00

8460.00

- +
200mg

￥0.00

0.00

- +
500mg

￥0.00

0.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajcx14996
CAS: 252003-71-7
别名:
分子式: C20H25BrClF2N5O3S
分子量: 568.86
纯度: >98%
溶解度: DMSO: 38.33 mg/mL (67.38 mM); Water: < 0.1 mg/mL (insoluble)
储存: Store at -20°C
库存: 现货

Background

CP 547,632 is an orally bioavailable and potent inhibitor of the receptor tyrosine kinases VEGF receptor 2 (VEGFR2) and basic fibroblast growth factor (bFGF) with IC₅₀ values of 11 and 9 nM, respectively, in an enzyme assay.¹ It is selective for VEGFR2 and bFGF over EGFR, PDGF receptor β (PDGFRβ), and related tyrosine kinases. CP 547,632 inhibits VEGFR2 autophosphorylation induced by VEGF in porcine aortic endothelial cells transfected with VEGFR2 (IC₅₀ = 6 nM) and in a xenograft mouse model using NIH3T3/H-Ras cells (EC₅₀ = 590 nM). It decreases angiogenesis induced by VEGF or bFGF and suppresses tumor growth in athymic mice.

1.Beebe, J.S., Jani, J.P., Knauth, E., et al.Pharmacological characterization of CP-547,632, a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for cancer therapyCancer Res.63(21)7301-7309(2003)