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- TNF Receptor
- Lanraplenib succinate
Lanraplenib succinate
A Syk inhibitor
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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1mg￥437.00350.00- +
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5mg￥1350.001080.00- +
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10mg￥2287.001830.00- +
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25mg￥3612.002890.00- +
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50mg￥6037.004830.00- +
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100mg￥10250.008200.00- +
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200mg￥0.000.00- +
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500mg￥0.000.00- +
- 货号: ajcx15088
- CAS: 1800047-00-0
- 别名: GS-9876 succinate
- 分子式: C23H25N9O.3/2C4H6O4
- 分子量: 620.64
- 纯度: ＞98%
- 溶解度: DMSO: 83.33 mg/mL (134.26 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
Lanraplenib is an inhibitor of spleen tyrosine kinase (Syk; IC50 = 6.2 nM).1 It is selective for Syk over a panel of 395 kinases but does inhibit JAK2 (IC50 = 120 nM). Lanraplenib reduces anti-IgM- and anti-CD40-induced proliferation of isolated human B cells (EC50 = 108 nM). It also inhibits immune complex-induced production of TNF-α, IL-1β, and IL-6 in human macrophages (EC50s = 180, 90, and 700 nM, respectively). It reduces proteinuria and increases survival in the NZBWF1 mouse model of systemic lupus erythematosus (SLE).
1.Blomgren, P., Chandrasekhar, J., Di Paolo, J.A., et al.Discovery of lanraplenib (GS-9876): A once-daily spleen tyrosine kinase inhibitor for autoimmune diseasesACS Med. Chem. Lett.11(4)506-513(2020)
