Glabrol (Compound 1) 是从甘草根的乙醇提取物中分离得到的一种异戊二烯类黄酮,是一种有效且非竞争性的 ACAT (酰基辅酶 A:胆固醇酰基转移酶)抑制剂,对大鼠肝脏微粒体 ACAT 的 IC50 值为 24.6 μM。
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Glabrol (Compound 1), One isoprenyl flavonoid was isolated from ethanol extract of licorice roots, is a potent and non-competitive Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor with an IC50 value of 24.6 μM for rat liver microsomal ACAT activity[1].
Glabrol (Compound 1) decreases cholesteryl ester formation with an IC50 value of 26.0 μM in HepG2 cells[1].
[1]. Choi JH, et al. Glabrol, an acyl-coenzyme A: cholesterol acyltransferase inhibitor from licorice roots. J Ethnopharmacol. 2007 Apr 4;110(3):563-6.
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