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- Acetyl-CoA carboxylase (ACC)
- Cridanimod
Cridanimod
An inducer of type I interferon production
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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5mg￥762.00610.00- +
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10mg￥1300.001040.00- +
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50mg￥3775.003020.00- +
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100mg￥6475.005180.00- +
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200mg￥0.000.00- +
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500mg￥0.000.00- +
- 货号: ajcx15118
- CAS: 38609-97-1
- 别名: 吖啶酮乙酸
- 分子式: C15H11NO3
- 分子量: 253.26
- 纯度: ＞98%
- 溶解度: DMSO: 125 mg/mL (493.56 mM); Water: < 0.1 mg/mL (insoluble)
- 储存: Store at -20°C
- 库存: 现货
Background
Cridanimod is an inducer of type I interferon (IFN) production.1,2 It induces IRF3 phosphorylation, IFN-β production, and NF-κB activation in wild-type, but not in stimulator of interferon genes (STING) mutant, murine macrophages.1 In vivo, cridanimod (112-1,792 mg/kg) increases plasma levels of IFN in weanling and adult mice.2 Cridanimod inhibits viral infection in mouse models of Semliki forest, coxsackie B1, Columbia SK, herpes, and pseudorabies viruses with protective doses (PD50s) ranging from 17-320 mg/kg.3 It increases uterine expression of estrogen and progesterone receptors in ovariectomized rats.4 Cridanimod also reverses tamoxifen-induced decreases in progesterone receptor expression in young rats.
1.Cavlar, T., Deimling, T., Ablasser, A., et al.Species-specific detection of the antiviral small-molecule compound CMA by STINGEMBO J.32(10)1440-1450(2013) 2.Taylor, J.L., Schoenherr, C.K., and Grossberg, S.E.High-yield interferon induction by 10-carboxymethyl-9-acridanone in mice and hamstersAntimicrob. Agents Chemother.18(1)20-26(1980) 3.Kramer, M.J., Cleeland, R., and Grunberg, E.Antiviral activity of 10-carboxymethyl-9-acridanoneAntimicrob. Agents Chemother.9(2)233-238(1976) 4.Surkov, K.G., Tsyrlina, E.V., Konstantinova, M.M., et al.Neovir, an interferon inductor, modifies expression of steroid hormone receptors in hormone-dependent tissues and restores sensitivity to tamoxifen in patients with inoperable breast cancerVopr. Onkol.42(6)28-32(1996)
