Dimercaprol (Bal, 2,3-Dimercapto-1-propanol, Dithioglycerol) is an acrolein scavenger that inhibits HIV-1 tat activity, viral production, and infectivity in vitro.
Dimercaprol (Bal, 2,3-Dimercapto-1-propanol, Dithioglycerol) is an acrolein scavenger that inhibits HIV-1 tat activity, viral production, and infectivity in vitro.
Dimercaprol exerts its acrolein scavenging capability, significantly protects PC-12 cells from acrolein-mediated cell death in a dose dependent manner.[3]
Dimercaprol could significantly reduce acrolein contents in spinal cord tissue following a spinal cord contusion injury in rats.[3]
[1] Ran Tian, Riyi Shi. J Neurochem. 2017 Jun;141(5):708-720. [2] S Kubota, et al. AIDS Res Hum Retroviruses. 1990 Jul;6(7):919-27. [3] Tian R, et al. J Neurochem. 2017 Jun;141(5):708-720.
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