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- AR-C102222 hydrochloride
AR-C102222 hydrochloride
AR-C102222 hydrochloride 是一种有效的、竞争性的、有口服活性的、高度选择性的诱导型一氧化氮合酶 (iNOS) 抑制剂，IC50 值为 37 nM。AR-C102222 hydrochloride 具有镇痛和抗炎活性。
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包装价格促销价数量
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1mg￥2062.001650.00- +
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5mg￥6200.004960.00- +
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10mg￥10575.008460.00- +
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50mg￥0.000.00- +
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100mg￥0.000.00- +
- 货号: ajcx15256
- CAS: 1781934-50-6
- 别名:
- 分子式: C19H17ClF2N6O
- 分子量: 418.83
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
AR-C102222 hydrochloride is a potent, competitive, orally active and highly selective inducible nitric oxide synthase (iNOS) inhibitor, with an IC50 of 37 nM[1]. AR-C102222 hydrochloride has antinociception and anti-inflammatory activities[2].
AR-C102222 (3, 10, 30, 100 mg/kg, P.O.) attenuates arachidonic acid-induced ear inflammation and possesses anti-inflammatory activity[2].AR-C102222 shows good efficacy in a rat adjuvant-induced arthritis model[3]. Animal Model: Male Balb/c mice (20-25 g)[2].
[1]. Tinker AC, et al. 1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo. J Med Chem. 2003 Mar 13;46(6):913-6. [2]. LaBuda CJ, et al. Antinociceptive activity of the selective iNOS inhibitor AR-C102222 in rodent models of inflammatory, neuropathic and post-operative pain. Eur J Pain. 2006 Aug;10(6):505-12. Epub 2005 Aug 24. [3]. Yoon J, et al. Syntheses of 1,2,3-triazolyl salicylamides with inhibitory activity on lipopolysaccharide-induced nitric oxide production. Bioorg Med Chem Lett. 2011 Apr 1;21(7):1953-7.
