AS2863619 free base

A dual inhibitor of Cdk8 and Cdk19

原价

￥1887-15700

价格

￥ 1510-12560

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产品引用

Cell.Cell host & microbe.November 8, 2023
Cell . MOLECULAR PLANT . 1 February 2023
Cell . Immunity . August 10, 2021
Nature Communications.1413 (2022)
ACS . Nano Lett . April 10, 2023

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Background

AS-2863619 is a dual inhibitor of cyclin-dependent kinase 8 (Cdk8) and Cdk19 (IC₅₀s = 0.6 and 4.3 nM, respectively).¹ It induces Foxp3 expression in isolated mouse na?ve T cells when used at a concentration of 1 ?M alone or synergistically in combination with TGF-β. AS-2863619 (30 mg/kg) decreases ear edema and induces production of Foxp3⁺ regulatory T cells (Tregs) in mice. It also reduces disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE).

1.Sakaguchi, S., Ohkura, N., Mikami, N., et al.Novel compound, and method for producing regulatory T cells(2019)

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生命科学

有机化学

无机化学

材料科学

AS2863619 free base

AS2863619 free base详情

Background