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- RIP kinase
- CKI-7
CKI-7
A CK1 inhibitor
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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1mg￥550.00440.00- +
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5mg￥925.00740.00- +
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10mg￥1625.001300.00- +
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25mg￥4037.003230.00- +
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50mg￥6737.005390.00- +
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100mg￥11962.009570.00- +
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200mg￥0.000.00- +
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500mg￥0.000.00- +
- 货号: ajcx15294
- CAS: 120615-25-0
- 别名:
- 分子式: C11H12ClN3O2S
- 分子量: 285.75
- 纯度: ＞98%
- 溶解度: DMSO: 25 mg/mL (87.49 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
CKI-7 is an inhibitor of casein kinase 1 (CK1; Ki = 8.5 μM).1 It is selective for CK1 over CK2, PKC, CaM kinase II (CaMKII), and cyclic AMP-dependent protein kinase (IC50s = 90, >1,000, 195, and 550 μM, respectively). CKI-7 inhibits phosphorylation of a peptide substrate by Leishmania CK1.2 by 50% when used at a concentration of 10 μM.2
1.Chijiwa, T., Hagiwara, M., and Hidaka, H.A newly synthesized selective casein kinase I inhibitor, N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide, and affinity purification of casein kinase I from bovine testisJ. Biol. Chem.264(9)4924-4927(1989) 2.Rachidi, N., Taly, J.F., Durieu, E., et al.Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infectionAntimicrob. Agents Chemother.58(3)1501-1515(2014)
