A phenolic acid with antibacterial and anticancer activities
Ginkgolic acid C17:1 is a phenolic acid that has been found in G. biloba with antibacterial and anticancer activities.1,2 It inhibits enterohemorrhagic E. coli O157:H7 (EHEC) biofilm formation when used at a concentration of 5 ?g/ml.1 Ginkgolic acid C17:1 (50 ?M) inhibits JAK2 phosphorylation and STAT3 activation in, and reduces the viability of, U266 cells.2
1.Lee, J.-H., Kim, Y.-G., Ryu, S.Y., et al.Ginkgolic acids and Ginkgo biloba extract inhibit Escherichia coli O157:H7 and Staphylococcus aureus biofilm formationInt. J. Food Microbiol.17447-55(2014) 2.Baek, S.H., Lee, J.H., Kim, C., et al.Ginkgolic acid C 17:1, derived from Ginkgo biloba leaves, suppresses constitutive and inducible STAT3 activation through induction of PTEN and SHP-1 tyrosine phosphataseMolecules22(2)276(2017)
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