JWG-071
JWG-071 是首次报道的 ERK5 激酶选择性化学探针。JWG-071 提高了 ERK5 活性和 BRD4 选择性。JWG-071 将是反卷积 ERK5 和 BRD4 药理学急需的化学探针。
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
-
包装价格促销价数量
-
1mg￥275.00220.00- +
-
5mg￥875.00700.00- +
-
10mg￥1412.001130.00- +
-
25mg￥2775.002220.00- +
-
50mg￥4850.003880.00- +
已选
0
种
0
瓶
金额:
￥0.00
首页
收藏
- 货号: ajcx15392
- CAS: 2250323-50-1
- 别名:
- 分子式: C34H44N8O3
- 分子量: 612.76
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
JWG-071 is the first reported kinase-selective chemical probe for ERK5. JWG-071 improves ERK5 activity and BRD4 selectivity. JWG-071 will be a much-needed chemical probe for deconvoluting ERK5 and BRD4 pharmacology[1].
JWG-071 inhibits ERK5 and LRRK2 with IC50 of 88 and 109 nM, respectively[1].
[1]. Wang J, et al. Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinonesas Inhibitors of Kinases and Bromodomains. ACS Chem Biol. 2018 Sep 21;13(9):2438-2448
