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- 5-ALA benzyl ester hydrochloride
5-ALA benzyl ester hydrochloride
5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) 是一种用作光检测器的原卟啉前体。5-ALA benzyl ester hydrochloride 诱导原卟啉 IX (PPIX) 在结肠癌细胞系中的积聚。
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包装价格促销价数量
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10mg￥700.00560.00- +
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25mg￥1412.001130.00- +
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50mg￥2400.001920.00- +
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100mg￥3987.003190.00- +
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200mg￥0.000.00- +
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500mg￥0.000.00- +
- 货号: ajcx15548
- CAS: 163271-32-7
- 别名: 5-氨基酮戊酸苄酯盐酸盐,Benzyl-ALA hydrochloride
- 分子式: C12H16ClNO3
- 分子量: 257.71
- 纯度: ＞98%
- 溶解度: DMSO: 250 mg/mL (970.08 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) is a protoporphyrin precursor used as a photodetection agent. 5-ALA benzyl ester hydrochloride induces protoporphyrin IX (PPIX) accumulation in colon carcinoma cell lines[1][2].
5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) (0.6-0.12 mM; 3 h) induces protoporphyrin IX (PPIX) accumulation in colon carcinoma cell lines SW480[2].
Reducing the dose of 5-ALA benzyl ester hydrochloride (31 mg/kg; i.v. ; 1 hours) results in a dose-dependent reduction in tumour porphyrin levels[3]. Animal Model: Female CBA/Gy mouse (CaNT tumour model)[3]
[1]. Hirschberg H, et al. ALA- and ALA-ester-mediated photodynamic therapy of human glioma spheroids. J Neurooncol. 2002 Mar;57(1):1-7. [2]. Brunner H, et al. The effects of 5-aminolevulinic acid esters on protoporphyrin IX production in human adenocarcinoma cell lines. Photochem Photobiol. 2001 Nov;74(5):721-5. [3]. Tunstall RG, et al. Porphyrin accumulation induced by 5-aminolaevulinic acid esters in tumour cells growing in vitro and in vivo. Br J Cancer. 2002 Jul 15;87(2):246-50.
