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ONC206 is a selective antagonist of dopamine D2-like receptors (DRD2/3/4) with broad-spectrum anti-tumor activity.
ONC206 is a selective antagonist of dopamine D2-like receptors (DRD2/3/4) with broad-spectrum anti-tumor activity.
ONC206 is a ClpP agonist regarding the requirement of high doses (50–130?mg/kg) to achieve in vivo efficacy. [2]
[1] Varun Vijay Prabhu, et al. Cancer Res 2017;77(13 Suppl):Abstract nr 4147A. [2] Fennell EMJ, et al. Pharmacol Res Perspect. 2022 Aug;10(4):e00993.
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