A furanocoumarin with diverse biological activities
(+)-Oxypeucedanin hydrate is a furanocoumarin that has been found in A. japonica and has diverse biological activities.1,2,3 It is active against the Gram-positive bacteria B. cereus, S. aureus, and S. faecalis (MICs = 9.76-78.12 ?g/ml), the Gram-negative bacteria E. coli, S. dysenteriae, P. aeruginosa, K. pneumoniae, and S. typhi (MICs = 39.06-625 ?g/ml), and the fungi C. albicans and M. audouinii (MIC = 39.06 ?g/ml for both).2 (+)-Oxypeucedanin hydrate inhibits proliferation of human MK-1 gastric and HeLa cervical cancer cells, as well as murine B16/F10 melanoma cells (EC50s = 47.2, 80.3, and 42 ?g/ml, respectively).1 It also inhibits proliferation of sensitive and multidrug-resistant murine L5178Y lymphoma cells (IC50s = 41.96 and 60.58 ?M, respectively).3
1.Fujioka, T., Furumi, K., Fuhii, H., et al.Antiproliferative constituents from Umbelliferae plants. V. A new furanocoumarin and falcarindiol furanocoumarin ethers from the root of Angelica japonicaChem. Pharm. Bull. (Tokyo)47(1)96-100(1999) 2.Dongfack, M.D.J., Lallemand, M.-C., Kuete, V., et al.A new sphingolipid and furanocoumarins with antimicrobial activity from Ficus exasperataChem. Pharm. Bull. (Tokyo)60(8)1072-1075(2012) 3.Mottaghipisheh, J., Nové, M., Spengler, G., et al.Antiproliferative and cytotoxic activities of furocoumarins of Ducrosia anethifoliaPharm. Biol.56(1)658-664(2018)
动态评分
0.0