Methyl syringate (Syringic Acid Methyl Ester), a plant phenolic compound, is a specific and selective TRPA1 agonist.
Methyl syringate (Syringic Acid Methyl Ester), a plant phenolic compound, is a specific and selective TRPA1 agonist.
Methyl syringate increases cytosolic Ca2+ in human TRPA1 (hTRPA1)-transfected cells[1]. Methyl syringate selectively activated hTRPA1 (EC(50) = 507.4 μM), but not hTRPV1[2].
Methyl syringate regulates food intake and gastric emptying through a TRPA1-mediated pathway and, by extension, can contribute to weight suppression in ICR mice[1].
[1] Kim MJ, et al. PLoS One. 2013, 8(8):e71603. [2] Son HJ, et al. Arch Pharm Res. 2012, 35(12):2211-8. [3] Park J, et al. Phytomedicine. 2016, 23(3):324-9.
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