A naphthoquinone with diverse biological activities
Lapachol is a naphthoquinone originally isolated from T. impetiginosa and has diverse biological activities.1,2,3,4,5 It is larvicidal against T. canis when used at a concentration of 2 mg/ml.1 Lapachol (10 and 100 ?M) inhibits topoisomerase I and topoisomerase II activities, as well as induces apoptosis and DNA damage in C6 rat glioma cells.2 It reduces B. atrox venom phospholipase A2 (PLA2) activity in a turbidimetric assay when used at a concentration of 10 ?g/ml.3 Lapachol (3 and 10 mg/kg) reduces synovial leukocyte infiltration and joint destruction in a mouse model of collagen-induced arthritis.4 It also reduces carrageenan-induced paw edema and abscess formation in rats.5
1.Mata-Santos, T., Pinto, N.F., Mata-Santos, H.A., et al.Anthelmintic activity of lapachol, β-lapachone and its derivatives against Toxocara canis larvaeRev. Inst. Med. Trop. Sao Paulo57(3)197-204(2015) 2.Xu, H., Chen, Q., Wang, H., et al.Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase IIJ. Exp. Clin. Cancer Res.35(1)178(2016) 3.Strauch, M.A., Tomaz, M.A., Monteiro-Machado, M., et al.Lapachol and synthetic derivatives: In vitro and in vivo activities against Bothrops snake venomsPLoS One14(1)(2019) 4.Peres, R.S., Santos, G.B., Cecilio, N.T., et al.Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritisArthritis Res. Ther.19(1)47(2017) 5.de Almeida, E.R., da Silva Filho, A.A., do Santos, E.R., et al.Antiinflammatory action of lapacholJ. Ethnopharmacol.29(2)239-241(1990)
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