A secoiridoid glycoside with diverse biological activities
Secoxyloganin is a secoiridoid glycoside that has been found in L. japonica and has diverse biological activities.1,2,3 It is active against E. coli and S. aureus in a disc assay when used at a concentration of 2 mg/disc.1 Secoxyloganin is cytotoxic to human dermal fibroblasts (IC50 = 78.1 ?M).2 In vivo, secoxyloganin (10 mg/ml) prevents hen egg white lysozyme-induced decreases in tail vein blood flow, a marker of allergic inflammation, in hen egg white lysozyme-sensitized mice.3
1.Xiong, J., Li, S., Wang, W., et al.Screening and identification of the antibacterial bioactive compounds from Lonicera japonica Thunb. leavesFood Chem.138(1)327-333(2013) 2.Zebiri, I., Haddad, M., Duca, L., et al.Biological activities of triterpenoids from Poraqueiba sericea stemsNat. Prod. Res.31(11)1333-1338(2017) 3.Oku, H., Ogawa, Y., Iwaoka, E., et al.Allergy-preventive effects of chlorogenic acid and iridoid derivatives from flower buds of Lonicera japonicaBiol. Pharm. Bull.34(8)1330-1333(2011)
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