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Lefamulin acetate

A pleuromutilin antibiotic

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Lefamulin acetate的二维码
  • 库存: 现货
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  • 包装
    价格
    促销价
    数量
  • 1mg
    ¥900.00
    720.00
    - +
  • 5mg
    ¥1887.00
    1510.00
    - +
  • 10mg
    ¥2837.00
    2270.00
    - +
  • 25mg
    ¥5625.00
    4500.00
    - +
已选 0 0
金额: ¥0.00
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  • 货号: ajcx16104
  • CAS: 1350636-82-6
  • 别名: 醋酸来法莫林,BC-3781 acetate
  • 分子式: C30H49NO7S
  • 分子量: 567.78
  • 纯度: >98%
  • 溶解度: DMSO: ≥ 100 mg/mL (176.12 mM); Water: < 0.1 mg/mL (insoluble)
  • 储存: Store at -20°C
  • 库存: 现货

Background

Lefamulin is a pleuromutilin antibiotic.1 It is active against methicillin-resistant S. aureus (MRSA), S. pyogenes, E. faecium, H. influenzae, M. catarrhalis, L. pneumonophilia, C. pneumoniae, and M. pneumoniae (MIC50s = 0.006-1 ?g/ml). Lefamulin is also active against fluoroquinolone- and macrolide-resistant strains of N. gonorrhoeae (MIC90s = 1 mg/L for all). In vivo, lefamulin (10-40 mg/kg) reduces the number of colony-forming units (CFUs) in a mouse model of S. pneumoniae thigh infection.2 It also reduces LPS-induced production of TNF-α, IL-6, IL-1β, and GM-CSF, bronchoalveolar lavage fluid (BALF) neutrophil infiltration, and lung matrix metalloproteinase-9 (MMP-9) levels in a mouse model of LPS-induced neutrophilia.3 Formulations containing lefamulin have been used in the treatment of community-acquired bacterial pneumonia (CABP).


1.Veve, M.P., and Wagner, J.L.Lefamulin: Review of a promising novel pleuromutilin antibioticPharmacotherapy38(9)935-946(2018) 2.Wicha, W.W., Craig, W.A., and Andes, D.In vivo pharmacodynamics of lefamulin, the first systemic pleuromutilin for human use, in a neutropenic murine thigh infection modelJ. Antimicrob. Chemother.74(Suppl 3)iii5-iii10(2019) 3.Hafner, M., Paukner, S., Wicha, W.W., et al.Anti-inflammatory activity of lefamulin versus azithromycin and dexamethasone in vivo and in vitro in a lipopolysaccharide-induced lung neutrophilia mouse modelPLoS One16(9)e0237659(2022)

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