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- HDAC (Histone deacetylases)
- 1-Naphthohydroxamic acid
1-Naphthohydroxamic acid
1-Naphthohydroxamic acid是强效、细胞渗透性和选择性组蛋白脱乙酰酶抑制剂 (HDAC8) 抑制剂（IC?50?= 14 μM）。在体外有抗癌活性。
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包装价格促销价数量
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5mg￥700.00560.00- +
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10mg￥1300.001040.00- +
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50mg￥4850.003880.00- +
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100mg￥8100.006480.00- +
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200mg￥0.000.00- +
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500mg￥0.000.00- +
- 货号: ajcx16204
- CAS: 6953-61-3
- 别名: 1-萘羟肟酸
- 分子式: C11H9NO2
- 分子量: 187.19
- 纯度: ＞98%
- 溶解度: DMSO: 125 mg/mL (667.77 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM. 1-Naphthohydroxamic acid is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity[1][2].1-Naphthohydroxamic acid can induce tubulin acetylation[3].
[1]. Krennhrubec K, et al. Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett. 2007 May 15;17(10):2874-8. [2]. Oehme I, et al. Histone deacetylase 8 in neuroblastoma tumorigenesis. Clin Cancer Res. 2009 Jan 1;15(1):91-9.
