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  • Valepotriate
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Valepotriate

A valepotriate with diverse biological activities

原价
¥1612-4600
价格
1290-3680
Valepotriate的二维码

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  • 货号: ajcx16240
  • CAS: 18296-44-1
  • 别名: 戊曲酯,Valtrate
  • 分子式: C22H30O8
  • 分子量: 422.47
  • 纯度: >98%
  • 溶解度: Soluble in DMSO
  • 储存: -20°C, protect from light
  • 库存: 现货

Background

Valtrate is a valepotriate that has been found in Valeriana and has diverse biological activities.1,2,3 It inhibits nuclear export of influenza virus ribonucleoprotein complex (vRNP) in HeLa cells when used at a concentration of 3.6 ?M and inhibits influenza virus infection in MDCK cells (IC50 = 0.19 ?M).1 Valtrate is cytotoxic to GLC-4 lung and COLO 320 colorectal cancer cells (IC50s = 1.4 and 3 ?M, respectively).2 It increases the number of entries into, and percentage of time spent in, the open arms of the elevated plus maze, indicating anxiolytic-like activity, and decreases serum corticosterone levels in rats when administered at a dose of 10 mg/kg.3


1.Watanabe, K., Takatsuki, H., Sonoda, M., et al.Anti-influenza viral effects of novel nuclear export inhibitors from Valerianae Radix and Alpinia galangaDrug Discov. Ther.5(1)26-31(2016) 2.Bos, R., Hendriks, H., Scheffer, J.J., et al.Cytotoxic potential of valerian constituents and valerian tincturesPhytomedicine5(3)219-225(1998) 3.Shi, S.-N., Shi, J.-L., Liu, Y., et al.The anxiolytic effects of valtrate in rats involves changes of corticosterone levelsEvid. Based Complement. Alternat. Med.325948(2014)

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