Valepotriate

A valepotriate with diverse biological activities

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库存: 现货

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5mg

￥1612.00

1290.00

- +
10mg

￥2550.00

2040.00

- +
20mg

￥4600.00

3680.00

- +

已选 0 种 0 瓶

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Background

Valtrate is a valepotriate that has been found in Valeriana and has diverse biological activities.^1,2,3 It inhibits nuclear export of influenza virus ribonucleoprotein complex (vRNP) in HeLa cells when used at a concentration of 3.6 ?M and inhibits influenza virus infection in MDCK cells (IC₅₀ = 0.19 ?M).¹ Valtrate is cytotoxic to GLC-4 lung and COLO 320 colorectal cancer cells (IC₅₀s = 1.4 and 3 ?M, respectively).² It increases the number of entries into, and percentage of time spent in, the open arms of the elevated plus maze, indicating anxiolytic-like activity, and decreases serum corticosterone levels in rats when administered at a dose of 10 mg/kg.³

1.Watanabe, K., Takatsuki, H., Sonoda, M., et al.Anti-influenza viral effects of novel nuclear export inhibitors from Valerianae Radix and Alpinia galangaDrug Discov. Ther.5(1)26-31(2016) 2.Bos, R., Hendriks, H., Scheffer, J.J., et al.Cytotoxic potential of valerian constituents and valerian tincturesPhytomedicine5(3)219-225(1998) 3.Shi, S.-N., Shi, J.-L., Liu, Y., et al.The anxiolytic effects of valtrate in rats involves changes of corticosterone levelsEvid. Based Complement. Alternat. Med.325948(2014)