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- TNF Receptor
- YQ128
YQ128
An NLRP3 inflammasome inhibitor
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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5mg￥1625.001300.00- +
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10mg￥2725.002180.00- +
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50mg￥7012.005610.00- +
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100mg￥11337.009070.00- +
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200mg￥0.000.00- +
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500mg￥0.000.00- +
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- 货号: ajcx16396
- CAS: 2454246-18-3
- 别名:
- 分子式: C27H29ClN2O4S2
- 分子量: 545.11
- 纯度: ＞98%
- 溶解度: DMSO: 250 mg/mL (458.62 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
YQ-128 is an inhibitor of the NOD-like receptor protein 3 (NLRP3) inflammasome (IC50 = 0.3 ?M).1 It inhibits LPS- and ATP-induced IL-1β release from isolated mouse peritoneal macrophages (IC50 = 1.59 ?M). YQ-128 (10 mg/kg) inhibits LPS-induced IL-1β production in wild-type but not Nlrp3-/- mice.
1.Jiang, Y., He, L., Green, J., et al.Discovery of second-generation NLRP3 inflammasome inhibitors: Design, synthesis, and biological characterizationJ. Med. Chem.62(21)9718-9731(2019)
