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  • AZD7325
AZD7325的可视化放大

AZD7325

A positive allosteric modulator of α2- and α3 subunit-containing GABAA receptors

原价
¥1150-5500
价格
920-4400
AZD7325的二维码

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  • 货号: ajcx16448
  • CAS: 942437-37-8
  • 别名: BAER-101
  • 分子式: C19H19FN4O2
  • 分子量: 354.38
  • 纯度: >98%
  • 溶解度: DMSO: 250 mg/mL (705.46 mM)
  • 储存: Store at -20°C
  • 库存: 现货

Background

AZD 7325 is a positive allosteric modulator of α2- and α3 subunit-containing GABAA receptors and a neutral antagonist for α1 subunit-containing GABAA receptors.1 It binds to GABAA receptors in membranes from Sf9 cells expressing α2β3γ2 subunit-containing receptors (Ki = 0.309 nM). AZD 7325 (1 mg/kg) increases marble-burying behavior, indicating anxiety-like activity, and decreases audiogenic seizure severity in the Fmr1-/- mouse model of fragile X syndrome.2


1.Alhambra, C., Becker, C., Blake, T.A., et al.Development and SAR of functionally selective allosteric modulators of GABAA receptorsBioorg. Med. Chem.19(9)2927-2938(2011) 2.Schaefer, T.L., Ashworth, A.A., Tiwari, D., et al.GABAA alpha 2,3 modulation improves select phenotypes in a mouse model of fragile X syndromeFront. Psychiatry12678090(2021)

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