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Cotadutide acetate (MEDI0382 acetate) 是胰高血糖素样肽-1 (GLP-1) 和胰高血糖素受体 (glucagon receptor) 的有效双重肽激动剂,EC50 值分别为 6.9 pM 和 10.2 pM。Cotadutide acetate (MEDI0382 acetate) 有促进减肥和控制血糖的能力,有潜力用于肥胖症和 2 型糖尿病 (T2D) 的研究。
Cotadutide acetate (MEDI0382 acetate) is a potent peptide dual agonist of glucagon-like peptide-1 (GLP-1) and glucagon receptor with EC50 values of 6.9 pM and 10.2 pM, respectively. Cotadutide acetate (MEDI0382 acetate) exhibits ability to facilitate both weight loss and glycaemic control, has the potential for obesity and type 2 diabetes (T2D) treatment[1].
[1]. Henderson SJ,et al. Robust anti-obesity and metabolic effects of a dual GLP-1/glucagon receptor peptide agonist in rodents and non-human primates.Diabetes Obes Metab. 2016 Dec;18(12):1176-1190.
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