Desethyl chloroquine diphosphate

Desethyl chloroquine diphosphate 是 Chloroquine 的主要去乙基代谢产物。Chloroquine 是一种自噬和 toll-like receptors (TLRs) 的抑制剂。Desethyl chloroquine diphosphate 具有抗疟原虫活性。

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库存: 现货

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5mg

￥4312.00

3450.00

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10mg

￥6475.00

5180.00

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25mg

￥9387.00

7510.00

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50mg

￥14962.00

11970.00

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100mg

￥24037.00

19230.00

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货号: ajcx16506
CAS: 247912-76-1
别名: 脱乙基氯喹二磷酸盐
分子式: C16H28ClN3O8P2
分子量: 487.81
纯度: >98%
溶解度: Soluble in DMSO
储存: 4°C, protect from light, stored under nitrogen
库存: 现货

Background

Desethyl chloroquine diphosphate is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine diphosphate possesses antiplasmodic activity[1][2].

[1]. Ajayi FO, et al. Comparison of the partitioning in vitro of chloroquine and its desethyl metabolites between the erythrocytes and plasma of healthy subjects and those with falciparum malaria. Afr J Med Med Sci. 1989 Jun;18(2):95-100. [2]. Vodicka P, et al. Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice. J Huntingtons Dis. 2014;3(2):159-74. [3]. Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193(12):6135-43.