GS-443902 sodium

GS-443902 sodium (GS-441524 triphosphate trisodium) 是一种有效的病毒 RNA 依赖性 RNA 聚合酶 (RdRp) 抑制剂，对 RSV RdRp 和 HCV RdRp 的 IC50 分别为 1.1 μM, 5 μM。

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
1mg

￥10575.00

8460.00

- +
5mg

￥20837.00

16670.00

- +
10mg

￥31525.00

25220.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajcx16532
CAS: 1355050-21-3
别名: 瑞德西韦代谢物三钠盐; GS-441524 triphosphate trisodium; Remdesivir metabolite trisodium
分子式: C12H16N5O13P3.xNa
分子量:
纯度: >98%
溶解度: Soluble in DMSO
储存: -20°C, sealed storage, away from moisture and light,unstable in solution, ready to use.
库存: 现货

Background

GS-443902 sodium (GS-441524 triphosphate sodium) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively. GS-443902 sodium is the active triphosphate metabolite of Remdesivir (GS-5734)[1][2]

Reference:
[1]. Siegel D, et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. Med Chem. 2017 Mar 9;60(5):1648-1661.
[2]. Cho A, et al. Synthesis and antiviral activity of a series of 1’-substituted 4-aza-7,9-dideazaadenosine C-nucleosides. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2705-7.
[3]. Warren TK, et al. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature. 2016 Mar 17;531(7594):381-5.