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- PBD-150
PBD-150
A glutaminyl cyclase inhibitor
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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5mg￥1625.001300.00- +
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10mg￥2987.002390.00- +
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50mg￥8100.006480.00- +
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- 货号: ajcx16598
- CAS: 790663-33-1
- 别名:
- 分子式: C15H20N4O2S
- 分子量: 320.41
- 纯度: ＞98%
- 溶解度: DMSO: 125 mg/mL (390.13 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
PBD-150 is an inhibitor of glutaminyl cyclase (Ki = 0.49 ?M for the human enzyme).1 It inhibits the formation of the pyroglutamic acid-containing amyloid-β (Aβ) peptides pGlu-Aβ (3-40) and pGlu-Aβ (3-42) in HEK293 cells expressing human glutaminyl cyclase and human amyloid precursor protein (APP) with an N-terminal deletion of the first two amino acids.1
1.Buchholz, M., Heiser, U., Schilling, S., et al.The first potent inhibitors for human glutaminyl cyclase: Synthesis and structure-activity relationshipJ. Med. Chem.49(2)664-677(2006)
