A Cdk2 and Cdk5 inhibitor
PNU 112455A is an inhibitor of cyclin-dependent kinase 2 (Cdk2) and Cdk5 (Ki = 2 ?M for both).1 It inhibits hyperphosphorylation of tau and cell death induced by the synthetic glucocorticoid dexamethasone in PC12 rat adrenal medulla cells expressing human tau when used at concentrations of 1 and 10 ?M.2
1.Clare, P.M., Poorman, R.A., Kelley, L.C., et al.The cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanismJ. Biol. Chem.276(51)48292-48299(2001) 2.Sotiropoulos, I., Catania, C., Riedemann, T., et al.Glucocorticoids trigger Alzheimer disease-like pathobiochemistry in rat neuronal cells expressing human tauJ. Neurochem.107(2)385-397(2008)
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