A synthetic estrogen
Promestriene is a synthetic estrogen and derivative of estradiol .1 Topical application of a gel containing promestriene (1%) reduces vaginal atrophy and decreases in endometrial and myometrial wall thickness in ovariectomized rats.2 Formulations containing promestriene have been used in the treatment of vaginal atrophy.
1.Del Pup, L., Di Francia, R., Cavaliere, C., et al.Promestriene, a specific topic estrogen. Review of 40 years of vaginal atrophy treatment: Is it safe even in cancer patients?Anticancer Drugs24(10)989-998(2013) 2.López-Belmonte, J., Nieto, C., Estevez, J., et al.Comparative uterine effects on ovariectomized rats after repeated treatment with different vaginal estrogen formulationsMaturitas72(4)353-358(2012)
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