A steroidal sapogenin with diverse biological activities
Yamogenin is a steroidal sapogenin that has been found in fenugreek (T. foenum graecum) and has diverse biological activities.1,2 It inhibits activation of the liver X receptor (LXR) induced by the LXRα and LXRβ agonist T0901317 in HepG2 cells in a reporter assay when used at concentrations of 5 or 10 ?M.1 Yamogenin (10 ?M) decreases triglyceride levels in primary mouse hepatocytes. It is cytotoxic to HaCaT keratinocytes, as well as HeLa cervical and SKOV3 ovarian cancer cells (IC50s = 16.4, 19.6, and 23.9 ?g/ml, respectively).2
1.Moriwaki, S., Murakami, H., Takahashi, N., et al.Yamogenin in fenugreek inhibits lipid accumulation through the suppression of gene expression in fatty acid synthesis in hepatocytesBiosci. Biotechnol. Biochem.78(7)1231-1236(2014) 2.Stefanowicz-Hajduk, J., Kól-Kogus, B., Sparzak-Stefanowska, B., et al.Cytotoxic activity of standardized extracts, a fraction, and individual secondary metabolites from fenugreek seeds against SKOV-3, HeLa and MOLT-4 cell linesPharm. Biol.59(1)424-437(2021)
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