BRD3308

An HDAC3 inhibitor

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库存: 现货

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5mg

￥987.00

790.00

- +
10mg

￥1737.00

1390.00

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25mg

￥3262.00

2610.00

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50mg

￥4650.00

3720.00

- +

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Background

BRD3308 is an inhibitor of histone deacetylase 3 (HDAC3; K_i = 29 nM).¹ It is selective for HDAC3 over HDAC1 and HDAC2 (K_is = 6,300 and 5,100 nM, respectively). BRD3308 (10 ?M) reduces cytokine-induced increases in apoptosis in rat INS-1E β cells. In vivo, BRD3308 (5 mg/kg) reduces plasma glucose levels in rats and increases plasma insulin levels in rats in a hyperglycemic clamp assay as a model of type 2 diabetes.²

1.An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell ProtectionACS Chem. Biol.11(2)363-374(2016) 2.Lundh, M., Galbo, T., Poulsen, S.S., et al.Histone deacetylase 3 inhibition improves glycaemia and insulin secretion in obese diabetic ratsDiabetes Obes. Metab.17(7)703-707(2015)