SR-318
A dual inhibitor of p38α and p38β MAPKs
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包装价格促销价数量
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5mg￥1212.00970.00- +
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10mg￥1962.001570.00- +
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50mg￥6262.005010.00- +
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100mg￥10250.008200.00- +
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- 货号: ajcx16888
- CAS: 2413286-32-3
- 别名:
- 分子式: C27H33N5O2
- 分子量: 459.58
- 纯度: ＞98%
- 溶解度: DMSO: 125 mg/mL (271.99 mM)
- 储存: 4°C, protect from light
- 库存: 现货
Background
SR 318 is a dual inhibitor of p38α and p38β MAPKs (IC50s = 5 and 32 nM, respectively).1 It is selective for p38α and p38β MAPKs over a panel of 468 kinases at 1 ?M. SR 318 inhibits LPS-induced TNF-α release in isolated human whole blood (IC50 = 0.283 ?M).
1.R?hm, S., Berger, B.-T., Schr?der, M., et al.Fast iterative synthetic approach toward identification of novel highly selective p38 MAP kinase inhibitorsJ. Med. Chem.62(23)10757-10782(2019)
