- 首页
- NO Synthase
- Nimesulide D5
Nimesulide D5
An internal standard for the quantification of nimesulide
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
-
包装价格促销价数量
-
1mg￥4312.003450.00- +
- 货号: ajcx16906
- CAS: 1330180-22-7
- 别名: 尼美舒利 D5
- 分子式: C13H7D5N2O5S
- 分子量: 313.34
- 纯度: ＞98%
- 溶解度: Methanol: soluble
- 储存: Store at -20°C
- 库存: 现货
Background
Nimesulide-d5 is intended for use as an internal standard for the quantification of nimesulide by GC- or LC-MS. Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) and COX-2 inhibitor (IC50s = 1.27 and 0.03 ?M for the human and ovine enzymes, respectively).1,2 It is selective for COX-2 over COX-1 (IC50s = 70 and 22 ?M for the human and ovine enzymes, respectively). Nimesulide also inhibits sodium-dependent neutral amino acid transporter (B0AT1) with an IC50 value of 23 ?M for the rat kidney transporter.3 It inhibits infection-induced increases in brain prostaglandin E2 levels, as well as reduces pyresis (ED50 = 0.3 mg/kg), in yeast-infected rats.4 Nimesulide (2.9 mg/kg) inhibits formalin-induced hindpaw thermal hyperalgesia in rats.5
1.Johnson, J.L., Wimsatt, J., Buckel, S.D., et al.Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledonsArch. Biochem. Biophys.324(1)26-34(1995) 2.Barnett, J., Chow, J., Ives, D., et al.Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus systemBiochim. Biophys. Acta1209(1)130-139(1994) 3.Pochini, L., Seidita, A., Sensi, C., et al.Nimesulide binding site in the B0AT1 (SLC6A19) amino acid transporter. Mechanism of inhibition revealed by proteoliposome transport assay and molecular modellingBiochem. Pharmacol.89(3)422-430(2014) 4.Taniguchi, Y., Yokoyama, K., Inui, K., et al.Inhibition of brain cyclooxygenase-2 activity and the antipyretic action of nimesulideEur. J. Pharmacol.330221-229(1997) 5.Bianchi, M., and Broggini, M.Anti-hyperalgesic effects of nimesulide: Studies in rats and humansInt. J. Clin. Pract. Suppl.57(128)11-19(2002)
