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- CCR (Chemokine receptors)
- ML604086
ML604086
ML604086 是一种选择性的 CCR8 抑制剂，抑制循环T细胞上 CCL1 与 CCR8 结合。ML604086 抑制 CCL1 介导的趋化作用，增加细胞内 Ca2+浓度。
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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5mg￥2175.001740.00- +
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10mg￥3775.003020.00- +
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50mg￥12825.0010260.00- +
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- 货号: ajcx17032
- CAS: 850330-18-6
- 别名:
- 分子式: C27H32N4O4S
- 分子量: 508.63
- 纯度: ＞98%
- 溶解度: Methanol: 125 mg/mL (245.76 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
ML604086 is a selective CCR8 inhibitor, inhibiting CCL1 binding to CCR8 on circulating T-cells. ML604086 inhibits CCL1 mediated chemotaxis and increases in intracellular Ca2+ concentrations[1][2].
[1]. James E. Pease, et al. Chemokine Receptors in Allergy, Inflammation, and Infectious Disease. Top Med Chem (2015) 14: 1-40. [2]. Lin Wang, et al. Antagonism of chemokine receptor CCR8 is ineffective in a primate model of asthma. Thorax 2013;68:506-512.
