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An inhibitor of HIV-1 capsid protein
PF-3450074 (PF74) is an inhibitor of HIV-1 capsid protein.1 It reduces viral infectivity in HeLa cells infected with wild-type HIV-1 but not P38A, E45A, Q63A/Q67A, or Q219A capsid protein mutant HIV-1, simian immunodeficiency virus, or murine leukemia virus when used at a concentration of 10 ?M. PF74 (0.62-10 ?M) reduces capsid protein levels in HIV-1 viral cores.
1.Shi, J., Zhou, J., Shah, V.B., et al.Small-molecule inhibition of human immunodeficiency virus type 1 infection by virus capsid destabilizationJ. Virol.85(1)542-549(2011)
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