A benzylisoquinoline alkaloid with diverse biological activities
Scoulerine is a benzylisoquinoline alkaloid that has been found in C. cava and has diverse biological activities.1,2,3 It selectively binds to the dopamine D1 and D2 receptors (Kis = 22 and 214 nM, respectively) over the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT2A in HEK293 cells when used at a concentration of 10 ?M.1 Scoulerine inhibits proliferation in a panel of leukemia cell lines (IC50s = 2.7-6.5 ?M).2 It inhibits methamphetamine-induced conditioned place preference in mice when administered at a dose of 5 mg/kg.3
1.Sun, H., Zhu, L., Yang, H., et al.Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D1, D2 and serotonin 5-HT1A multi-action profileBioorg. Med. Chem.21(4)856-868(2013) 2.Habartova, K., Havelek, R., Seifrtova, M., et al.Scoulerine affects microtubule structure, inhibits proliferation, arrests cell cycle and thus culminates in the apoptotic death of cancer cellsSci. Rep.8(1)4829(2018) 3.Mi, G., Gao, Y., Yan, H., et al.l-Scoulerine attenuates behavioural changes induced by methamphetamine in zebrafish and miceBehav. Brain Res.298(Pt A)97-104(2016)
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