all-trans Retinoic Acid-d5
An internal standard for the quantification of all-trans retinoic acid
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包装价格促销价数量
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500ug￥3625.002900.00- +
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1mg￥6112.004890.00- +
- 货号: ajcx17436
- CAS: N/A
- 别名: atRA-d5, RA-d5, Vitamin A Acid-d5
- 分子式: C20H23D5O2
- 分子量: 305.5
- 纯度: ＞98%
- 溶解度: DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 0.5 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
all-trans Retinoic acid-d5 is intended for use as an internal standard for the quantification of all-trans retinoic acid by GC- or LC-MS. all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC50 values of 9, 3, and 10 nM for RARα, RARβ, and RARγ, respectively, in radioligand binding assays. It induces expression of a luciferase reporter in COS-7 cells expressing RARα, RARβ, or RARγ (EC50s = 169, 9, and 2 nM, respectively). all-trans Retinoic acid (12 nmol) reduces papilloma formation induced by phorbol 12-myristate 13-acetate in mice. It reduces bile duct proliferation, hydroxyproline levels, and liver inflammation in a rat model of α-naphthylisothiocyanate-induced chronic cholestasis and reduces plasma levels of alkaline phosphatase and bile salts in the Mdr2-/- mouse model of cholestasis. all-trans Retinoic acid also reduces hepatic fat accumulation, triglycerides, body weight, and serum glucose levels in mice with Western diet-induced obesity.
