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A truncated form of rat adrenomedullin
Adrenomedullin (11-50) is a truncated form of rat adrenomedullin. Intravenous administration of adrenomedullin (11-50) (3-10 μg/animal) decreases mean systemic arterial pressure in rats in a dose-dependent manner without affecting cardiac output. Cerebroventricular injection of adrenomedullin (11-50) (88 pmol) reduces water intake in response to angiotensin II , overnight water deprivation, and hyperosmotic challenge in rats.
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